Evaluation of blood coagulation by reflective laser measurement analysis

• Main Authors: Yen, Shih-Chieh, 顏士傑
• Other Authors: 鄭泗東
• Format: Others
• Language: zh-TW
• Published: 2013
• Online Access: http://ndltd.ncl.edu.tw/handle/38797548801075938259

碩士 === 國立交通大學 === 機械工程系所 === 102 === The analysis of blood coagulation tests is an important basis for surgery, cardiovascular disease, chronic disease complications and hemophilia. It’s always use the automatic coagulation analyzer to detect the blood prothrombin time in tradition. But, the automatic coagulation analyzer is so expensive, bulky, higher costs, and the long duration of detection. In recent years, the direction of research in the optical biosensor is to test dynamic blood coagulation from a standard blood sample, but it’s required fairly wide space to set the experimental equipment and environment. Further, it’s often use the CCD camera be receiver in a penetration type optical measurement system. In order to show the dynamic curve, these signals need numerical calculation in computer analysis. Therefore, this research is mainly using reflective optical system to detect the human whole blood coagulation. A 635nm red laser is to irradiate the whole blood of human on the reflective mirror, and the feedback light is received by the photodiode. Finally, the light intensity is converted into voltage, and then calculated the trend of the voltage change. We can achieve the purpose is the coagulation test by analysis of abnormal coagulation and clotting time length. In addition, our optical detection system is less demand in both whole-blood and plasma samples. The most important is that non-contact detection can reduce the effect of clotting mechanism. It provides a fast, convenient and low-cost optical bio-detection technology to the biomedical sphere.