| Summary: | 碩士 === 國立中央大學 === 機械工程學系在職專班 === 102 === Safety and reliability are crucial issues to medical instruments and implants. In the past few decays, bulk metallic glass draw lots attentions due to their excellent mechanical properties, good corrosion resistance, antibacterial and good biocompatibility, and were considered as an ideal candidate for medical related implants.
Three Ni-free bulk metallic glasses include the Zr42Cu42Al8Ag8, Zr48Cu36Al8Ag8 and Ti40Zr10Cu36Pd14 were studied and evaluated their potential as medical implants. The glassy nature and composition of these three bulk metallic glasses were firstly confirmed by X-ray diffraction analysis and energy dispersive spectrometer. The surface roughness examined by atomic force microscope, all samples perform nano-meter-scale surface roughness. Several biocompatibility tests were carrying out to evaluate these three bulk metallic glasses co-cultural with L929 murine fibroblast cell line. The results of cellular adhesion behavior, cytotoxic, and metallic ion release affection. The optima biocompatibility results occur at Ti40Zr10Cu36Pd14 bulk metallic glass, cell still attached on the petri dish with good adhesion and exhibit the spindle shape after direct contact test. Furthermore, the Ti40Zr10Cu36Pd14 sample showed the lowest Ni and Cu ion release level which correlate to MTT results. Based on the data mentioned above, we believe that Ti40Zr10Cu36Pd14 bulk metallic glass can be one of ideal candidates for medical implant materials.
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