Synthetic study of cyclopeptide JBP485、JBP923 and lipopeptide Lauryl (C-12)-CK2H2 (DDTAB)

• Main Authors: GU, Yi-Jia, 古宜加
• Other Authors: Lee, Yean-Jang
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/29f47h

碩士 === 國立彰化師範大學 === 化學系 === 102 === There are a lot of special bioactive polypeptides were isolated from natural products. JBP485 and JBP923, a dipeptide, was first isolated from Laennec, which is a purified hydrolysate from human placenta. Our strategy is that using commercially available L-Serine and trans-4-hydroxyproline as starting materials. Dipeptide was derived from peptide coupling by using PyBOP and DIPEA. After by cyclization complete the natural product. Conclusion we using four pathways to accomplish of JBP485: (a) 5 steps, yield:27% ；(b) 5 steps, yield:12%；(c) 6 steps, yield:14%；(d) 7 steps, yield:18%；. and the overall steps and yield of JBP923: 8 steps, 24%. Lauryl(C-12)-CK2H2, Our strategy is that using commercially availableLauric acid、L-Cysteine、L-Histidine、L-Lysine as starting materials.