Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan
博士 === 國立中山大學 === 生物科學系研究所 === 102 === Organisms in the genus Aquilaria (Thymelaeaceae) are widely distributed in Asia. Previous phytochemical investigation on Chinese agarwood revealed characteristic sesquiterpenes and chromone derivatives, but the chemical constituents in each part of the agarwood...
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ndltd-TW-102NSYS51120092017-04-22T04:32:28Z http://ndltd.ncl.edu.tw/handle/53439424744503417836 Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan 台灣產白木香化學成份之研究 Ching-tong Chen 陳晴彤 博士 國立中山大學 生物科學系研究所 102 Organisms in the genus Aquilaria (Thymelaeaceae) are widely distributed in Asia. Previous phytochemical investigation on Chinese agarwood revealed characteristic sesquiterpenes and chromone derivatives, but the chemical constituents in each part of the agarwood is not clear. The chemical constituents in the wood and bark of Aquilaria sinensis were separated with column chromatography. Twelve compounds, including four flavonoids, 5-hydroxy-7,4′-dimethoxyflavone, 5-hydroxy-7,3′,4′-trimethoxyflavone, 5,3′-dihydroxy-7,4′-dimethoxyflavone and 5,4′-dihydroxy-7,3′-dimethoxyflavone , three benzenoids, vanillic acid , p-hydroxybenzoic acid , and syringic acid , one quinol, 4-acetonyl -3,5-dimethoxy-p-quinol, two amides, N-trans-feruloyltyramine and N-cis-feruloyltyramine , one lignan, (+)-syringaresinol and one steroid, β-sitostenone were isolated from the wood of A. sinensis. Eight compounds, including five flavonoids, 5-hydroxy-7,4′-dimethoxyflavone, 5,4′-dihydroxy-7-methoxyflavone , 5-hydroxy -7,3′,4′-trimethoxyflavone , 5,3′-dihydroxy-7,4′-dimethoxyflavone and 5,4′-dihydroxy-7,3′-dimethoxyflavone , one benzenoid, methylparaben , one lignan, (+)-syringaresinol and one steroid, β-sitosterol were isolated from the bark of A. sinensis. All of these compounds were obtained for the first time from this plant. The anti-cancer activities of 5-hydroxy-7,4′-dimethoxyflavone, 5,4′-dihydroxy-7-methoxyflavone, 5-hydroxy-7,3′,4′-trimethoxyflavone, 5,3′-dihydroxy-7,4′-dimethoxyflavone on melanoma were examined. Results indicated that the anti-cancer effects of these four compounds increase with the increasing doses. David Chao Chung Yi Chen 趙大衛 陳中一 2014 學位論文 ; thesis 126 zh-TW |
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博士 === 國立中山大學 === 生物科學系研究所 === 102 === Organisms in the genus Aquilaria (Thymelaeaceae) are widely distributed in Asia. Previous phytochemical investigation on Chinese agarwood revealed characteristic sesquiterpenes and chromone derivatives, but the chemical constituents in each part of the agarwood is not clear. The chemical constituents in the wood and bark of Aquilaria sinensis were separated with column chromatography. Twelve compounds, including four flavonoids, 5-hydroxy-7,4′-dimethoxyflavone, 5-hydroxy-7,3′,4′-trimethoxyflavone, 5,3′-dihydroxy-7,4′-dimethoxyflavone and 5,4′-dihydroxy-7,3′-dimethoxyflavone , three benzenoids, vanillic acid , p-hydroxybenzoic acid , and syringic acid , one quinol, 4-acetonyl -3,5-dimethoxy-p-quinol, two amides, N-trans-feruloyltyramine and N-cis-feruloyltyramine , one lignan, (+)-syringaresinol and one steroid, β-sitostenone were isolated from the wood of A. sinensis. Eight compounds, including five flavonoids, 5-hydroxy-7,4′-dimethoxyflavone, 5,4′-dihydroxy-7-methoxyflavone , 5-hydroxy -7,3′,4′-trimethoxyflavone , 5,3′-dihydroxy-7,4′-dimethoxyflavone and 5,4′-dihydroxy-7,3′-dimethoxyflavone , one benzenoid, methylparaben , one lignan, (+)-syringaresinol and one steroid, β-sitosterol were isolated from the bark of A. sinensis. All of these compounds were obtained for the first time from this plant. The anti-cancer activities of 5-hydroxy-7,4′-dimethoxyflavone, 5,4′-dihydroxy-7-methoxyflavone, 5-hydroxy-7,3′,4′-trimethoxyflavone, 5,3′-dihydroxy-7,4′-dimethoxyflavone on melanoma were examined. Results indicated that the anti-cancer effects of these four compounds increase with the increasing doses.
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author2 |
David Chao |
author_facet |
David Chao Ching-tong Chen 陳晴彤 |
author |
Ching-tong Chen 陳晴彤 |
spellingShingle |
Ching-tong Chen 陳晴彤 Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan |
author_sort |
Ching-tong Chen |
title |
Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan |
title_short |
Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan |
title_full |
Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan |
title_fullStr |
Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan |
title_full_unstemmed |
Studies on the Chemical Constituents from Aquilaria sinensis Grown in Taiwan |
title_sort |
studies on the chemical constituents from aquilaria sinensis grown in taiwan |
publishDate |
2014 |
url |
http://ndltd.ncl.edu.tw/handle/53439424744503417836 |
work_keys_str_mv |
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