The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide

The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide

碩士 === 國立清華大學 === 化學系 === 102 === This thesis dealt with the synthesis and application of novel prolinamide-camphor organocatalysts that derived from the coupling of trans-4-hydroxy-L-proline and camphorsulfonamide. Organocatalyst 11d is proven to be an efficient catalyst for the asymmetric Michael...

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Main Authors: Chen, Yi-Ju, 陳怡如
Other Authors: 汪炳鈞
Format: Others
Language:zh-TW
Published: 2014
Online Access:http://ndltd.ncl.edu.tw/handle/r36ctc
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spelling ndltd-TW-102NTHU50651252019-05-15T21:42:04Z http://ndltd.ncl.edu.tw/handle/r36ctc The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide 樟腦磺醯胺衍生之胺化合物與(2S,4R)-4-羥基-L-脯胺酸之縮合物催化酮類化合物對查耳酮衍生物進行不對稱Michael反應之研究 Chen, Yi-Ju 陳怡如 碩士 國立清華大學 化學系 102 This thesis dealt with the synthesis and application of novel prolinamide-camphor organocatalysts that derived from the coupling of trans-4-hydroxy-L-proline and camphorsulfonamide. Organocatalyst 11d is proven to be an efficient catalyst for the asymmetric Michael reaction of ketone and a series of chalcone-derived. Treatment of cyclohexanone with chalcone- deriveds which have electron-withdrawing group using organocatalyst 11d provided the desired Michael products with high chemical yields (up to 97% yield), excellent diastereoselectivities (up to 99/1 dr) and high levels of enantioselectivities (up to 93% ee) for syn- products. 汪炳鈞 2014 學位論文 ; thesis 190 zh-TW
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language zh-TW
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description 碩士 === 國立清華大學 === 化學系 === 102 === This thesis dealt with the synthesis and application of novel prolinamide-camphor organocatalysts that derived from the coupling of trans-4-hydroxy-L-proline and camphorsulfonamide. Organocatalyst 11d is proven to be an efficient catalyst for the asymmetric Michael reaction of ketone and a series of chalcone-derived. Treatment of cyclohexanone with chalcone- deriveds which have electron-withdrawing group using organocatalyst 11d provided the desired Michael products with high chemical yields (up to 97% yield), excellent diastereoselectivities (up to 99/1 dr) and high levels of enantioselectivities (up to 93% ee) for syn- products.
author2 汪炳鈞
author_facet 汪炳鈞
Chen, Yi-Ju
陳怡如
author Chen, Yi-Ju
陳怡如
spellingShingle Chen, Yi-Ju
陳怡如
The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide
author_sort Chen, Yi-Ju
title The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide
title_short The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide
title_full The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide
title_fullStr The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide
title_full_unstemmed The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide
title_sort study on asymmetric michael addition reaction of ketones to chalcones catalyzed by camphorsulfonamide-derived (2s,4r)-4-hydroxy-l-prolinamide
publishDate 2014
url http://ndltd.ncl.edu.tw/handle/r36ctc
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