| Summary: | 碩士 === 國立高雄大學 === 運動健康與休閒學系碩士班 === 102 === Since 1986, the newborns in Taiwan received hepatitis B vaccination, and the prevalence ofhepatitis Bcarriers dropped from 10% to below 1%. In recent years, however, the rate of negative anti-HBs was found over 53% at freshmen’s examination. This search investigates the relation among gender, HBsAg and anti-HBs, and analyzes the effectiveness of hepatitis B vaccination after adding one dose of vaccine.
Research Methods: Collecting the physical examination data of 26,108 freshmen in a certain university at southern Taiwan from 2006 to 2012, and analyzes the HBSAg and anti-HBs condition of 21,130 native university students who were born after July, 1986. We follow up the effectiveness of hepatitis B vaccination after adding one dose of vaccine and also investigate the relation among gender, age and the generation of the vaccine.
Results: The collected cases are 21,130(male 11,904, female 9226). The total of positive HBsAg is 518. 382 are 19 years old(2.3%), 83 are 20 years old( 3.0%), 33 are 21years old(2.7%), 20 are 22 years old( 3.0%). According to the data above, it shows significant correlation (p<0.05).The total of positive anti-HBs is 9,369. 5,069 are male(42.6%), and 4,300 are female(46.6%). According to the data above, it shows significant correlation (p<0.05), and at the rate of positive anti-HBs female are higher than male. The number of students who received plasma generation vaccine at their childhood is 7,359(45.9%), and it is 2,010(39.6%) at those received recombinant vaccine at their childhood, p<0.05. 201 students received adding one dose of vaccine. 158 students showed positive post-booster anti-HBs. 104(71.7%) are plasma generation vaccine group, and 54(96.4%) are recombinant vaccine group, p<0.05.
Conclusion:The HBsAg positive rate increased with age. The female’s anti-HBs positive rate is higher than male’s, and the positive rate of post-booster anti-HBs to is higher in recombinant vaccine group than in plasma generation vaccine group; the effect to evoke immune memory after adding one dose of hepatitis B vaccine, recombinant vaccine group is better. It is necessary for freshmen to examine hepatitis B. Booster hepatitis B vaccine for those both negative at HbsAg and anti-HBs is important to improve effectively the anti-HBs concentration and keep away from hepatitis B infection.
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