| Summary: | 碩士 === 國立臺北科技大學 === 化學工程研究所 === 102 === Electrospinning is an emerging nanometer process technology in recent years, which can directly and quickly changing into polymer nanofibers to improve specific surface area, porosity and pore structure , and more extensive in accordance with diverse materials to different applications .
In this study focused on the application of electrospinning technology is divided into two parts .The first part is the use of polycaprolactone(PCL) as the material .PCL is a bioabsorbable, biodegradable polymer that has attracted enormous attention in recent years due to good environmental compatibility, which is soluble in formic acid, acetic acid, chloroform or trifluoroethanol to form polymer solution .Here is the use of formic acid:acetic acid = 1:1 co-solvent system, and then were added in different proportions (0.2, 0.4, 0.6, 0.8, 1) of chitosan, silver nanoparticles and other with high antibacterial additions . A positive voltage of 16.5kV was applied for electrospinning of the 15%PCL solution and a grounded aluminum foil placed 20 cm from the tip of the needle was used as the optimal conditions to collect the nanofiber membranes.By SEM observation of the average diameter of the membranes about 350 to 400 nm, and found that increasing the amount of chitosan, silver nanoparticles will decline in mechanical testing. For antibacterial activity, the results indicated 0.2% of silver nanoparticles or chitosan is able to achieve widespread inhibition effecs. In order to achieve filter applications , a comprehensive analysis of the results in 15% PCL/0.6% silver nanoparticles of nanofiber membrane filter with the standards .
The second part is based on the same technology as the foundation of electrospinning .Polyvinyl alcohol(PVA) and gelatin polymer blend were prepared by using electrospinning technique and produced long-term, stable and versatility facial mask to improve specific surface area, obedient degree and high cost and other issues in the current market . Solutions of PVA and gelatin were 10% and 5%, respectively .
The distance between needle and collector was 25 cm and the applied voltage was 16.8kV with optimal parameters conditions .Tranexamic acid, magnesium ascorbyl phosphate (MAP), glycerin and other moisturizing, whitening ingredients to prepare nanofiber facial mask .Comparison of physical properties included the mechanical strength of the carrier and the drug release rate .The experimental results showed that, compared to the market mask carrier, mechanism strength significantly increased by approximately 11.2% stress and 105% strain performance .The average diameter of nanofiber was 6 to 8 μm .Spectrophotometer were measured the cumulative release rate of tranexamic acid and MAP after 30 minutes up to 20% and 60%, respectively . Then the final assessment test to use PVA /gelatin nanofiber mask does have potential of commercialization.
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