Pharmacokinetic and pharmacodynamic interaction of traditional Chinese herbal medicines on hydrochlorothiazide

• Main Authors: Chang-Yang Tan, 陳昌陽
• Other Authors: Tung-Hu Tsai
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/77582088019276841266

碩士 === 國立陽明大學 === 傳統醫藥研究所 === 102 === Hydrochlorothiazide is one of the most commonly prescribed drugs for the treatment of hypertension, heart failure, and nephritic syndrome. Wu-Ling powder (WLP) and Ling-Gui-Zhu-Gan Decoction (LGZGD) are typical Chinese herbal formulae used to dispel water retention. The aim of this study is to investigate the potential pharmacokinetic and pharmacodynamic interactions of hydrochlorothiazide with these two Chinese herbal formulations. Parallel experimental groups were designed to investigate the herb-drug interaction on pharmacokinetics and pharmacodynamics. A validated HPLC-UV method has been developed to explore the herb-drug interactions of LGZGD and WLP on the pharmacokinetics of hydrochlorothiazide in blood and kidney dialysates. The ACU, T1/2 and clearance of the hydrochlorothiazide in blood was 485 ± 66.3 min µg/mL, 57.0 ± 9.50 min and 20.2 ± 2.66 mL/min/kg, respectively. In kidney was 7491 ± 1159 min µg/mL, 87.3± 19.2 min and 1.38 ± 0.25 mL/min/kg, respectively. The combination of high doses of WLP and hydrochlorothiazide showed significant increase in clearance (1.83 ± 0.35 mL/min/kg) and decrease in the AUC (5537 ± 961 min µg/mL) of the kidney. In addition, the volume of urine excreted increase, along with enhancing the excretion of K+, Na+, and Cl- electrolytes. There was no significant interaction between hydrochlorothiazide and LGZGD. However, pretreated with LGZGD, there was a reduction of the Na+ and Cl- excretion. These findings indicate that combination treatment of hydrochlorothiazide and WLP may affect the pharmacokinetics of hydrochlorothiazide in the kidney and enhance adverse reactions. These results may provide some valuable clinical information about the interaction between hydrochlorothiazide and the traditional herbal formulations of LGZGD and WLP.