| Summary: | 碩士 === 國立中正大學 === 化學暨生物化學研究所 === 104 === In this thesis, we have studied N-heterocyclic carbene-mediated intramolecular Stetter reaction to construct tricyclic spiranes. The cyclic enal-enones were used as substrates in the studied. Treatment of 2-ethyl cyclic enal-enones with NHC has produced tricyclic spiranes in 54-72% yields. As well as, the use of 2-((3-oxocyclohex-1-en-1-yl)methyl)cyclohex-1- enecarbaldehyde as starting material has produced 4',5',6',7'-tetrahydrospiro- [cyclohexane-1,2'-indene]-1',3(3'H)-dione in 31% yield.
(tricyclic spiranes，N-heterocyclic carbene)
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