The correlation between high order aberration and factors including manifest refractive error, age, corneal shape, gender, pupil size and tear quality in Taiwan adults.

• Main Authors: Yu-Ling Cheng, 鄭郁齡
• Other Authors: John Ching-Jen Hsiao
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/17098482785621537895

碩士 === 中山醫學大學 === 生物醫學科學學系碩士班 === 103 === Background and Purpose: Apart from manifest refractive error, the quality of vision is affected by various factors. With the capability of analyzing most of the aberration in the eye, wavefront sensor has been widely used in many aspects of ophthalmic application. However, there were few analytical studies done regarding high-order aberration and its influencing factors. The purpose of this study is to analyze the distribution of ocular high-order aberration and to investigate its relationship with various physiological properties in Taiwanese adults. This retrospective study will help to better understand the effect of high-order aberration on human visual quality. Material and Method: This retrospective study data was obtained from 312 patients who underwent a comprehensive ocular-visual evaluation as a routine procedure prior to refractive laser surgery from the year 2008 to 2012. The age of the population ranged from 20 to 56.The spherical component of their manifest refraction ranged from -1.50D through -10.50 D. The cylinder component of the manifest refraction was less than -3.50 D.To obtain research data included basic information, auto- refractor measurement (TOPCON Auto Kerato-Refractometer KR-8900), subjective refraction, pupil size (in daylight and darkroom), Wavefront scan: AMO WaveScan WaveFront™ System (wavescan mode),corneal thickness, and tear test result.Data analysis: Statistical analysis was conducted using Statistical Package for Social Science (SPSS, PASW Statistics 18 SPSS18).Repeated-measures one way analysis of variance (One way ANOVA) was performed to examine the statistical significance of variations in aberrations between various groups. We were also used Independent-Samples t Test, Partial Correlation, and linear regression to compare groups and post hoc to check the correlation.Results:Our results showed the scotopic pupil size is significantly correlated with spherical aberration (r=0.154, F=0.007),coma (r=0.201, F=0.000), and trefoil (r=0.240, F=0.000). Spherical aberration and spherical equivalent are significantly correlated.(r=0.219, P=0.001).Spherical aberration increases with age, and they are positively correlated(r=0.193, F=0.002).Coma and astigmatism are significantly positively correlated(r=0.278, F=0.000).Trefoil and astigmatism are significantly correlated(r=-0.138, F=0.020). The spherical aberrations are different between genders. Spherical aberration is found to be higher in patients wearing RGP vs. Soft contact lens previously. Conclusion:Based on our result, the scotopic pupil size is significantly correlated to coma, trefoil and spherical aberration; therefore it has a great impact on the total higher-order aberration. Significant positive correlation was also found between spherical aberration and age, this suggests the compensation mechanism of spherical aberration between cornea and crystalline lens reduces with age. Although statistically we found many ocular physiological factors to be significantly correlated with higher-order aberrations, more research is needed to confirm the relationship. This project allows us to analyze the distribution of higher-order aberrations among Taiwanese adults and hopefully to identify its influencing factors and the effect on visual quality.