| Summary: | 碩士 === 高雄醫學大學 === 醫學系神經學科碩士班 === 103 === Obstructive sleep apnea (OSA) is a common sleep disorder characterized by chronic intermittent hypoxia and sleep fragmentation. Patients with OSA often complain poor attention, impaired vigilance and cognitive decline. Using comprehensive Frontal Test Battery, Flanker task and event-related potentials (P300, error-related negativity (ERN) and error positivity (Pe)), the aims of this study are 1) to evaluate the cognitive deficit, particularly action monitoring, 2) to investigate the effect of OSA on P300, ERN and Pe, and 3) to clarify the possible mechanism of cognitive dysfunction in patients with OSA syndrome.
25 OSA patients, based on polysomnography (PSG) (male: 19, mean age: 49.7 ± 8.6 years) and 12 normal controls (male: 6, mean age: 43.9 ± 8.7 years) underwent comprehensive Frontal Test Battery, Flanker task and event-related potentials assessments (P300, error-related negativity and error positivity).
In comparison with controls, the OSA patients showed significant impairment in global cognition, attention and high executive function. Besides, the OSA patients have lower correct rate and lower error correcting rate in Flanker task. The OSA patients also have significant prolonged P300 and ERN latencies.
Furthermore, the arousal index was significantly correlated with attention and performance of Flanker task. The oxygen desaturation index was significantly correlated with attention. The duration and severe of nocturnal hypoxia was significantly correlated with amplitude of ERN.
We conclude that the OSA patients may manifest with significant frontal dysfunction, mainly on attention, executive function and action monitoring. We suggest that the attentional impairment might be due to sleep fragmentation and intermittent hypoxia, and the impairment of action monitoring might be due to sleep fragmentation and severity of nocturnal hypoxia.
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