Cardiac CT evaluation of vascular distribution of calcified coronary plaque in asymptomatic subjects

• Main Authors: Chi-Shu Hsieh, 謝其書
• Other Authors: Pao-Shu Chang
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/792g75

碩士 === 高雄醫學大學 === 醫學影像暨放射科學系碩士在職專班 === 103 === Framingham risk scores, EKG, chest X-ray, troponin and interventional coronary angiography are usually used to predict the coronary artery disease(CAD). Atherosclerosis may be the indicative of CAD. Computed tomography examination is a non-invasive method to estimate of examinee’s coronary artery calcification. Agatston calcium score is a useful tool to calculate a score based on the extent of coronary artery calcification detected by and unenhanced low-dose CT scan. This work is to study the vascular distribution of calcified coronary plaque and the association of gender, smoke addict, and diabetes mellitus with the culprit location. There were 695 without cardiovascular disease examinee. In these examinee, male was 541 and female was 154, smoker was 410 and non-smoker was 285, and diabetes mellitus patient was 116, non-DM patient was 579, respectively. According to the four main coronary artery, which is RCA, LAD, LM, and LCX, 15 segment’s ROI of calcium were demarcated. Among these segments, No. 1,5,6 and 11 segments were demarcated to the proximal end of vessels, No.2,7,9 and 12 were to the midde vessels, No.3,4,8,10,13,14 and 15 were to the distal end of vessels. An ANOVA was applied for statistical analysis. The results show that there are 83% calcification distribution for the proximal and middle end of vessels, and only 17% calcification distribution for the distal end of vessels. To analyze the calcification features of the proximal, middle and distal end of vessels, the distant end of vessels has the lowest calcium density. For male examinee, the proximal and median end of vessels have the most calcium ratio. For female examinee, there is no significant difference(p>0.05) for calcium ratio. For sexual distinction, with/without smoke and with/without DM, the LAD and RCA get the higher distribution of calcification. For diabetes mellitus examinee, there is significant difference of the distribution of calcified plaque when examinee without diabetes mellitus. For examinee with diabetes mellitus, there is no significant difference(p >0.05), and the calcified plaque distribution shows diffuse. Another difference shows that the calcium distribution in LCX and LM is higher for the examinee with diabetes mellitus.