1. Syntheses of α-Thio-β-dicarbonyl Compounds through Oxidative Coupling Reaction2. Microwave-Assisted Oxidative Cross-Coupling Reaction of Aldehydes with Thiols

• Main Authors: Yi-Wei Liu, 劉奕緯
• Other Authors: Chin-Fa Lee
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/38296283359536613383

碩士 === 國立中興大學 === 化學系所 === 103 === K2S2O8/I2 promoted C-S coupling reaction of β-diketone with disulfide has been described. The resulting α-thio-β-diketones compounds were obtained in good to excellent yields. Both diaryl and dialkyl disulfides are coupled well with a variety of β-diketones under metal-free and solvent-free conditions. A very simple microwave-promoted synthesis of thioesters through the coupling of thiols and aldehydes under metal-free and solvent-free conditions was reported. This system shows good functional group tolerance, functional groups including bromo, iodo, nitrile, trifluoromethyl, thiophene and pyridine are all tolerated under the reaction conditions employed. Both aryl and alkyl thiols are coupled smoothly with a broad spectrum of aldehydes to afford the corresponding thioesters in good to excellent yields.