| Summary: | 碩士 === 國立中興大學 === 食品暨應用生物科技學系所 === 103 === Obesity, an excess of body fat accumulation is thought to be a risk factor for
cardiovascular diseases. One of the effective ways to prevent obesity is to
reduce the absorption of energy. Lipase inhibitor was a common antiobesity
agent which could reduce the fat absorption by inhibiting the activity of lipase.
Scientists are looking for the possibility of finding more and different natural
antiobesity agents. In this research, grape seed, mulberry twig, lotus leaf,
clove, blackcurrant, and ginseng extracts were processed into powder and
granule forms. The potency of these two forms of samples to interfere lipid
and starch absorption was evaluated.
In vitro results showed that grape seed and blackcurrant extracts could
inhibit 79.1% or 81.1% of α-amylase activity. The lipase inhibitory effect of
the grape seed, lotus leaf, clove, blackcurrant, and ginseng extracts were over
60% at the concentration of 0.015 g/ml. Then, plant extracts including grape
seed, lotus leaf, and ginseng extracts were evaluated by vivo assays. Assays of
residual fecal starch showed that no apparent differences among the powder,
granule, and high fat groups were observed. As compared with the powder
groups, granule groups were found to have slightly higher crude fat levels in
feces. For the ginseng extract, not only the powder group but also the granule
group had a significant increase in the crude fat in feces.
In conclusion, this research therefore suggested that ginseng extract had a
significant inhibitory effect on lipase, thereby interfering with the lipid
absorption. The process of granulation could increase the ability of plant
extract to higher the crude fat in feces.
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