| Summary: | 博士 === 國立中興大學 === 微生物暨公共衛生學研究所 === 103 === Influenza is a respiratory infection. It causes high mortality of annual epidemics and occasional pandemics in the past. Recently, Many new types of mutated influenza viruses have occurred. The outbreak of H5N1 avian flu in 2003 and the new type H1N1 human flu in 2009 have increased public vigilance of the potential for global influenza pandemics. Due to the emergence of neuraminidase inhibitor and M2 ion channel inhibitor resistant viruses, such as H5N1 and swine-origin H1N1 influenza viruses. Hence, new approaches for the control of infection with influenza viruses must be explored. In many reports, traditional Chinese medicinal herbs are considered a potential alternative medicine of choice for treatment of this disease. Peperomia sui Lin & Lu （P. sui）, a well-known Taiwanese folk medicine, has a broad range of biological effects, especially in treatment of upper respiratory tract diseases. In addition, Ixeris chinensis （Thunb.） Nakai （I. chinensis）, has been used to prepare a traditional Chinese medicine composition for prevention and treatment of influenza A viral infection. Until now the effects of P. sui and I. chinensis on the influenza virus have not been examined. In this study, the in vitro anti-influenza viral effect of P. sui and I. chinensis were evaluated. The 50% ethanol extract from P. sui and I. chinensis significantly increased the viability of in chicken fibroblast DF-1 cells that were infected by the A/Chicken/TW/0518/2011（H6N1） virus. This extract also suppressed the synthesis of viral nucleoprotein （NP）, and inhibited the propagation of the virus in DF-1 cells. Further, the 50% ethanol extract of P. sui and I. chinensis effectively inhibited the neuraminidase activity of H6N1 virus. Overall, these findings provide important information for the exploitation and utilization of P.sui and I. chinensis in prevention and treatment of influenza infection.
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