The Pilot Study on Anti-Fatigue Activities of Rhodiola Rosea Extracts

• Main Authors: LU,WEN-JUI, 盧文瑞
• Other Authors: HUANG, CHI-CHANG
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/76416969113522667233

碩士 === 國立體育大學 === 運動與健康科學學院 === 104 === Rhodiola rosea is one of the most famous medicinal herbs to fight against physical fatigue and has been purported to possess ergogenic properties. The purpose of this study is to evaluate whether the extracts of Rhodiola rosea is able to ameliorate the condition of physical fatigue, the effectiveness of performance enhancement, or anti-fatigue functions. We used ICR mice model to evaluate how the extract of Rhodiola rosea affect the physical fatigues, as well as to assess the relevant physiological and biochemical indices. A total of 15 male ICR mice were direved into three group (5 mice/group): (1) the control group without treatment, the treatment group with a dosage of the extracts of Rhodiola rosea (RE-1X), and the treatment group with double dosage of the extracts of Rhodiola rosea (RE-2X). After four weeks, all mice were tested for exercise performance and anti-fatigue functions, including forelimb grip strength, endurance performance in a 5% body weight-loaded swimming test, and serum levels of lactate, ammonia, glucose, urea nitrogen concentration, and creatine kinase after a 15-min exercise challenge. Results showed that RE-treated animals have a significant increase in grip strength and endurance swimming performance, and both in a dose-depend manner. In addition, RE-treated mice have a significant reduction of fatigue- or muscle injury-associated biomarkers: serum lactate, ammonia, and CK levels post an acute exercise challenge. In conclusion, our data confirmed that the extracts of Rhodiola rosea has a great potential as an ergogenic aid.