| Summary: | 博士 === 國立交通大學 === 應用化學系碩博士班 === 103 === Conventional cancer treatments have many limitations which often fail to completely eradicate the tumor and cause damages to normal cells. Photodynamic therapy (PDT), by the excitation of photosensitizers with light to generate reactive oxygen species (ROSs) such as 1O2, has emerged as a noninvasive technique for cancer theranostics. However, the clinical use of many photosensitizers has been challenged by their nonspecific damage to normal tissues, environmental degradation and hydrophobicity...etc. To overcome the existing limitation and to enhance the selectivity of photodynamic therapy, we developed a simple electrostatic adsorption strategy to fabricate silica nanocomposite (Apt-MB-Si NPs) by sequentially functionalizing MUC1 aptamer for tumor targeting and hydrophilic photosensitizer methylene blue (MB) for the PDT application. We found effective generation of singlet oxygen could be achieved with low PS dosage and short irradiation time by current strategy.
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