Changes in the concentrations of neurotransmitters caused by deep brain light stimulation of the substantia nigra pars compacta

• Main Authors: Lin,Zong-Shian, 林宗憲
• Other Authors: Liu,Jia-Ming
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/3g6nqc

碩士 === 國立交通大學 === 影像與生醫光電研究所 === 103 === Since the invention of the lasers more than fifty years ago, lasers have been used in a variety of biological and medical fields, including therapeutic clinical applications. From our previous research using EEG measurement, we acquired the optimal parameters for light stimulation of the active regions in the substantia nigra pars compacta (SNc). The primary goal of this thesis study is to measure the concentration changes in glutamate, lactate and glycerol in the striatum utilizing a microdialysis when the SNc is irradiated with the optimal parameters of light stimulation. The experimental results show that light stimulation with a laser power of 1 mW for 5 minutes causes the concentrations of glutamate and lactate to clearly decrease. This suggests that light stimulation of the SNc can modulate the concentrations of neurotransmitters in the striatum. The therapeutic strategy of light stimulation of the SNc for glutamate-related disease such as Parkinson’s disease is a subject that deserves serious attention in future biomedical research.