Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Effects of Baffle Configuration and Vessel Size on Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Spherical Agglomerates of Dimethyl Fumarate in a Common Agitated Tank Common Agitated Tank Common Agitated Tank Common Agitated TankCommon Agitated Tank Common Agitated Tank Common Agitated TankCommon
碩士 === 國立中央大學 === 化學工程與材料工程學系 === 103 === The aim of this thesis is to study the effects of baffle configuration and different vessel sizes on the spherical agglomeration process. Spherical agglomeration was operated in the 0.5 L-, 2 L-, 10 L-sized stirred vessels with the standard dimensions and t...
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| Format: | Others |
| Language: | en_US |
| Published: |
2015
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| Online Access: | http://ndltd.ncl.edu.tw/handle/cuc8w3 |
| Summary: | 碩士 === 國立中央大學 === 化學工程與材料工程學系 === 103 === The aim of this thesis is to study the effects of baffle configuration and different vessel sizes on the spherical agglomeration process. Spherical agglomeration was operated in the 0.5 L-, 2 L-, 10 L-sized stirred vessels with the standard dimensions and the arrangement of impeller diameter, impeller location and liquid level. The stirred vessel installed with the standard US vertical baffle type or the European baffle type, or the Kawashima baffle type was used to prepare the spherical agglomerates of dimethyl fumarate. Initial solvent screening was used to establish the form space of dimethyl fumarate for selecting the useful solvent combination in spherical agglomeration process. It was found that the particle size distribution of agglomerates prepared in the stirred vessel installed with different baffle types at the same operating conditions could vary significantly, and plenty of powders did not assemble into granules in the large size of vessel under the same operating conditions. The polymorphism of spherical agglomerates did not transform after cohering the powders into the granules, but the crystallinity of the agglomerates was slightly altered. The size-related properties, such as dissolution profile and flowability, of granules from the same size cut remained unchanged. The interior structure-related properties, such as density and mechanical property, of granules from the same size cut upon baffle change and scale up were decayed. However, granules could become denser and stronger by prolonged maturation time.
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