Synthetic study of cyclopeptide JBP485、JBP923 and intermediates and Pt (II)-peptide complex
碩士 === 國立彰化師範大學 === 化學系 === 103 === Recently , a lot of special bioactive peptides have been isolated from natural products. These peptides were synthesized by many chemists, moreover these peptide drugs could be used to treat a wide range of diseases. JBP485 and JBP923 are our main researched pepti...
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Others |
Language: | zh-TW |
Online Access: | http://ndltd.ncl.edu.tw/handle/hax3rh |
id |
ndltd-TW-103NCUE5065013 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-TW-103NCUE50650132019-05-15T22:25:31Z http://ndltd.ncl.edu.tw/handle/hax3rh Synthetic study of cyclopeptide JBP485、JBP923 and intermediates and Pt (II)-peptide complex 環胜肽JBP485、JBP923及其中間體和Pt (II)-peptide complex之合成研究 Wang,Yao-Ting 王耀霆 碩士 國立彰化師範大學 化學系 103 Recently , a lot of special bioactive peptides have been isolated from natural products. These peptides were synthesized by many chemists, moreover these peptide drugs could be used to treat a wide range of diseases. JBP485 and JBP923 are our main researched peptides which were isolated from human placenta, became they have good biological activity so that they have considerable potential in drug development. Our synthetic strategy is that using commercially available L-Serine and trans-4-hydroxy-L-Proline as the starting material for preparing the desired monomer, then, peptide bond synthesized to get the dipeptide skeleton, subsequently functional groups modified and condensation to complete synthesis of the natural product JBP485 and JBP923. These structures was confirmed by X-ray crystallography. The natural product JBP485 used N-Hydroxysuccinimide (NHS) and N,N'-Dicyclohexylcarbodiimide (DCC) to cyclization process. It may generate an activated ester (intermediate) during the cyclization. We hope to be able to find evidence of its existence Another project we thought about using JBP485 and JBP923 to synthesize Pt (II)-peptide complex which may have anti-cancer activity, but we are still preparing the precursor and the needs to be further identified for subsequent reactions. Lee, Yean-Jang 李衍彰 學位論文 ; thesis 47 zh-TW |
collection |
NDLTD |
language |
zh-TW |
format |
Others
|
sources |
NDLTD |
description |
碩士 === 國立彰化師範大學 === 化學系 === 103 === Recently , a lot of special bioactive peptides have been isolated from natural products. These peptides were synthesized by many chemists, moreover these peptide drugs could be used to treat a wide range of diseases. JBP485 and JBP923 are our main researched peptides which were isolated from human placenta, became they have good biological activity so that they have considerable potential in drug development.
Our synthetic strategy is that using commercially available L-Serine and trans-4-hydroxy-L-Proline as the starting material for preparing the desired monomer, then, peptide bond synthesized to get the dipeptide skeleton, subsequently functional groups modified and condensation to complete synthesis of the natural product JBP485 and JBP923. These structures was confirmed by X-ray crystallography.
The natural product JBP485 used N-Hydroxysuccinimide (NHS) and N,N'-Dicyclohexylcarbodiimide (DCC) to cyclization process. It may generate an activated ester (intermediate) during the cyclization. We hope to be able to find evidence of its existence
Another project we thought about using JBP485 and JBP923 to synthesize Pt (II)-peptide complex which may have anti-cancer activity, but we are still preparing the precursor and the needs to be further identified for subsequent reactions.
|
author2 |
Lee, Yean-Jang |
author_facet |
Lee, Yean-Jang Wang,Yao-Ting 王耀霆 |
author |
Wang,Yao-Ting 王耀霆 |
spellingShingle |
Wang,Yao-Ting 王耀霆 Synthetic study of cyclopeptide JBP485、JBP923 and intermediates and Pt (II)-peptide complex |
author_sort |
Wang,Yao-Ting |
title |
Synthetic study of cyclopeptide JBP485、JBP923 and intermediates and Pt (II)-peptide complex |
title_short |
Synthetic study of cyclopeptide JBP485、JBP923 and intermediates and Pt (II)-peptide complex |
title_full |
Synthetic study of cyclopeptide JBP485、JBP923 and intermediates and Pt (II)-peptide complex |
title_fullStr |
Synthetic study of cyclopeptide JBP485、JBP923 and intermediates and Pt (II)-peptide complex |
title_full_unstemmed |
Synthetic study of cyclopeptide JBP485、JBP923 and intermediates and Pt (II)-peptide complex |
title_sort |
synthetic study of cyclopeptide jbp485、jbp923 and intermediates and pt (ii)-peptide complex |
url |
http://ndltd.ncl.edu.tw/handle/hax3rh |
work_keys_str_mv |
AT wangyaoting syntheticstudyofcyclopeptidejbp485jbp923andintermediatesandptiipeptidecomplex AT wángyàotíng syntheticstudyofcyclopeptidejbp485jbp923andintermediatesandptiipeptidecomplex AT wangyaoting huánshèngtàijbp485jbp923jíqízhōngjiāntǐhéptiipeptidecomplexzhīhéchéngyánjiū AT wángyàotíng huánshèngtàijbp485jbp923jíqízhōngjiāntǐhéptiipeptidecomplexzhīhéchéngyánjiū |
_version_ |
1719130075847196672 |