Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa

• Main Authors: Chen-Ting Yin, 鄞辰庭
• Other Authors: Ping-Jyun Sung
• Format: Others
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/08855478589331247689

碩士 === 國立東華大學 === 海洋生物研究所 === 103 === 　　Studies on the chemical constituents of the cultured soft coral Sinularia numerosa have led to the isolation of five compounds, including three new norcembranoids, 4α-hydroxy-5-episinuleptolide (1), sinumerolide A (2) and 7E-sinumerolide A (3), along with two know compounds, 5-epi-sinuleptolide (4) and (+) 5,11-diepisinuleptolide (5). The structures of compounds 1－5 were established by spectroscopic method and by comparison of the spectral data with those known analogues. 　　Compounds 1, 4 and 5 were found to show cytotoxicity toward various tumor cells. Compound 1 was found to display inhibition on effects on the release of elastase (IC50 = 5.68 μg/mL) by human neutrophils. Compounds 2, 3 and 5 were found to display inhibition the accumulation of the pro-inflammatory iNOS protein in the LPS-stimulated RAW264.7 macrophage cells at a concentration of 10 μM.