Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa
碩士 === 國立東華大學 === 海洋生物研究所 === 103 === Studies on the chemical constituents of the cultured soft coral Sinularia numerosa have led to the isolation of five compounds, including three new norcembranoids, 4α-hydroxy-5-episinuleptolide (1), sinumerolide A (2) and 7E-sinumerolide A (3), along with two...
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ndltd-TW-103NDHU52770102016-07-31T04:22:08Z http://ndltd.ncl.edu.tw/handle/08855478589331247689 Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa 臺灣產聚集指型軟珊瑚Sinularia numerosa 所含二次代謝物之研究 Chen-Ting Yin 鄞辰庭 碩士 國立東華大學 海洋生物研究所 103 Studies on the chemical constituents of the cultured soft coral Sinularia numerosa have led to the isolation of five compounds, including three new norcembranoids, 4α-hydroxy-5-episinuleptolide (1), sinumerolide A (2) and 7E-sinumerolide A (3), along with two know compounds, 5-epi-sinuleptolide (4) and (+) 5,11-diepisinuleptolide (5). The structures of compounds 1-5 were established by spectroscopic method and by comparison of the spectral data with those known analogues. Compounds 1, 4 and 5 were found to show cytotoxicity toward various tumor cells. Compound 1 was found to display inhibition on effects on the release of elastase (IC50 = 5.68 μg/mL) by human neutrophils. Compounds 2, 3 and 5 were found to display inhibition the accumulation of the pro-inflammatory iNOS protein in the LPS-stimulated RAW264.7 macrophage cells at a concentration of 10 μM. Ping-Jyun Sung Jimmy Kuo 宋秉鈞 郭傑民 2015 學位論文 ; thesis 115 |
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碩士 === 國立東華大學 === 海洋生物研究所 === 103 === Studies on the chemical constituents of the cultured soft coral Sinularia numerosa have led to the isolation of five compounds, including three new norcembranoids, 4α-hydroxy-5-episinuleptolide (1), sinumerolide A (2) and 7E-sinumerolide A (3), along with two know compounds, 5-epi-sinuleptolide (4) and (+) 5,11-diepisinuleptolide (5). The structures of compounds 1-5 were established by spectroscopic method and by comparison of the spectral data with those known analogues.
Compounds 1, 4 and 5 were found to show cytotoxicity toward various tumor cells. Compound 1 was found to display inhibition on effects on the release of elastase (IC50 = 5.68 μg/mL) by human neutrophils. Compounds 2, 3 and 5 were found to display inhibition the accumulation of the pro-inflammatory iNOS protein in the LPS-stimulated RAW264.7 macrophage cells at a concentration of 10 μM.
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author2 |
Ping-Jyun Sung |
author_facet |
Ping-Jyun Sung Chen-Ting Yin 鄞辰庭 |
author |
Chen-Ting Yin 鄞辰庭 |
spellingShingle |
Chen-Ting Yin 鄞辰庭 Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa |
author_sort |
Chen-Ting Yin |
title |
Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa |
title_short |
Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa |
title_full |
Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa |
title_fullStr |
Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa |
title_full_unstemmed |
Studies on the Secondary Metabolites from the Formosan Soft Coral Sinularia numerosa |
title_sort |
studies on the secondary metabolites from the formosan soft coral sinularia numerosa |
publishDate |
2015 |
url |
http://ndltd.ncl.edu.tw/handle/08855478589331247689 |
work_keys_str_mv |
AT chentingyin studiesonthesecondarymetabolitesfromtheformosansoftcoralsinularianumerosa AT yínchéntíng studiesonthesecondarymetabolitesfromtheformosansoftcoralsinularianumerosa AT chentingyin táiwānchǎnjùjízhǐxíngruǎnshānhúsinularianumerosasuǒhánèrcìdàixièwùzhīyánjiū AT yínchéntíng táiwānchǎnjùjízhǐxíngruǎnshānhúsinularianumerosasuǒhánèrcìdàixièwùzhīyánjiū |
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