Synthesis of Indole, Indoline, Benzofuran and Chroman Derivatives from Nitroalkenes
碩士 === 國立臺灣師範大學 === 化學系 === 103 === The contents of the thesis is divided into two chapters, each chapter individually including preface, research goal, result and discussion, and conclusion. Chapter I deals with the copper-catalyzed Ullmann reaction to synthesize 3-arylindoles, in which the precu...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2015
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| Online Access: | http://ndltd.ncl.edu.tw/handle/79382536634409889369 |
| Summary: | 碩士 === 國立臺灣師範大學 === 化學系 === 103 === The contents of the thesis is divided into two chapters, each chapter individually including preface, research goal, result and discussion, and conclusion. Chapter I deals with the copper-catalyzed Ullmann reaction to synthesize 3-arylindoles, in which the precursors are furnished by AlCl3-catalyzed Friedel-Crafts alkylation of beta-nitrostyrenes and arenes followed by reduction.
Chapter II discuss about the applicability of beta-nitrostyrene derivatives for the synthesis of structurally three types of compounds. The chapter is divided into three parts, first part is about the synthesis of 2-benzylindoline from Ullmann coupling of amines, which are obtained by reduction of 2-bromo-arylsubstituted nitroalkenes. The second part is about synthesis of 2-benzylbenzofurans from nitroalkene derivatives derived from the reduction of 2-hydroxy-arylsubstituted nitroalkenes via Nef reaction. In the last part describes the synthesis of 2-arylchromans derivatives from 2-hydroxy-arylsubstituted nitroalkenes through base mediated intramolecular Michael addition.
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