| Summary: | 碩士 === 國立臺灣海洋大學 === 水產養殖學系 === 103 === The objective of this study was to investigate the nicotinic acid metabolism and absorption in hybrid tilapia ( Oreochromis niloticus #westeur024# O. niloticus ) by using modified cannulated urine collector in order to monitor the 24-hour changes of plasma and urine concentration of nicotinic acid, respectively. The analyses of the accumulated content of nicotinic acid in the liver and muscle tissues in the end of the 24-hour experimental duration after the exogenous input either by oral administration or caudal vein injection. The average weight of experimental fish was 892 ± 48g. nicotinic acid was either orally adminstrated at levels of 0, 40, 80, 120, 160 and 320 mg / kg body weight or caudal vein injection at 0, 7, 14, 21 and 42 ppm.
Plasma nicotinic acid level significantly elevated 1st hour after the initiation of the experiment, then peaked at 6th hour on all the treatment groups of fish orally forced fed diets containing various level of nicotinic acid than the control group.Nicotinic acid level in the plasma peaked at 1st hour on all the treatment groups after fish injected different levels of nicotinic acid. Nicotinic acid accumulation were capacity in the liver in the fed group ≧ 120 ppm with injected ≧ 7 ppm nicotinic acid solution.
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