| Summary: | 碩士 === 國立臺灣科技大學 === 醫學工程研究所 === 103 === In this study, we describes we synthesized a novel polyelectrolyte micorparticle, DOX-SPIO-CS/CHI MPs, as drug delivery systems (DDS) for hepatic cancer treatment. Also, we investigated the properties of these micropar-ticles, from material characterizations, formulation tests, in vitro study to in vivo study. The results show that our DOX-SPIO-CS/CHI MPs displays an average diameter of 110.7 nm (SD = 30.23), and reveals a spherical shape. The encapsu-lation efficiency of doxorubicin is about 31% (SD = 8.07) based on our spec-trometer measurement. In the results of release profile test, we found a sus-tained-release behavior of DOX-SPIO-CS/CHI MPs, which released 51.5% of DOX within 48 h of testing time. Based on the results of cell viability assay and animal study, the DOX-SPIO-CS/CHI MPs was found to show stronger ability than that of free DOX, when given to Hep G2 and Huh-6 human liver cancer cell line for treatment and nude mice of Hep G2/Huh-6-induced tumor model.
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