| Summary: | 碩士 === 國立臺北科技大學 === 有機高分子研究所 === 103 === This study was divided into two parts, the first part is using the redox polymerization method with N-isopropylacrylamide as the main body of the hydrogel, the hydrogel due to PNIPAAM polymer has hydrophilic and hydrophobic functional groups and there are temperature-sensitive behavior, but insoluble in water. Lower critical solution temperture (LCST) ≒ 32 ℃, is close to human body temperature. In recent years, the development of biomaterial application has been widely studied. In this study, we use IAM, which has both acid/base functional groups, as second monomer. Then we cross-linked the linear Poly (NIPAAM-co-IAM) by crosslinker. The result indicates that the LCST values of copolymers increased as hydrophilic monomer feed molar ratio of IAM. LCST ≒ 58 ℃, so swelling ratio is significantly increased.
The second part is also using the redox polymerization method with PNIPAAM as the main body of the microgel, and copolymerized with the monomer IAM. The result indicates that the LCST values of copolymers increased as hydrophilic monomer feed molar ratio of IAM. Dynamic light scattering (DLS) was observed with the increase of pH environment, weak acid groups on the copolymer chain is protonated, resulting particle size presented an expanded state. Moreover, in this study we found that the trends of LCST hydrogel and microgel was opposite, and attempted to explain the possible mechanisms.
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