Establish Dynamic Model of Human Brain and Discuss the Relation with Alzheimer’s Disease

• Main Authors: JIANG,ZHE-WEI, 江哲瑋
• Other Authors: WANG,FENG-SHENG
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/82209253938763060619

碩士 === 國立中正大學 === 化學工程研究所 === 104 === Sphingolipids are widely existed in the human body, they distribute in intracellular、extracellular and different organelles , and they can also be taken through diet. Sphingolipids are not only the main structure of the cell membrane but also can control cell’s death or survival via signaling. Sphingolipids have been linked to some human diseases such as Alzheimer’s disease and some kinds of cancer. Its metabolic pathway intermediates ceramide and sphingosine 1- phosphate are known as tumor- suppressor lipid and cancer-promoting lipid respective, but in neuro-degradation disease they are thought as pro-apoptotic molecule and anti-apoptotic molecule respective. In this research we are going to construct dynamic models that are related to Alzheimer’s disease, and then combines with literatures and bio-information to discuss how normal system turns into disease system by adjusting the parameters that are included in the model. By this way then we can try to find out the way to turn the disease condition back to normal condition through manipulating the disease related species like ceramide and sphingosine-1-phosphate. Also the metabolic balance including in lysosome, mitochondrion and endoplasmic reticulum that are important when disease happened. We will also discuss how the parameters manipulations influence the disease related species in those organelles and finally cause the disease to happen. Through this model research we might find some possible therapy targets or therapy methods to cure or delay the progression of Alzheimer’s disease.