| Summary: | 碩士 === 長庚大學 === 機械工程學系 === 104 === Postoperative pain and tissue adhesions are the main cause to make patients uncomfortable. The treatment of postoperative pain included injecting analgesic drugs to intravenous or muscle, nerve blocks or regional anesthesia. However, these drugs and administration usually have a short efficacy, systemic side effects and other complications. So it is easy to cause chronic pain and hyperalgesia after surgery.
This experiment used a poly(lactic-co-glycolic acid) (PLGA) to prepare drug-eluting anti-adhesion nanofibrous membranes, carrying the local anesthetic drug (Lidocaine) and nonsteroidal anti-inflammatory drug (Ketorolac). We observed the mechanic, drug release properties and the analgesic effect. The results showed the membrane has a nanofiber level, certain ductility, nontoxicity and both drugs can be stably released for at least 20 days. Finally, in vivo test showed that the membranes can significantly reduce pain and improve rats’ vitality. The wound also exhibited a good recovery after two weeks and fewer tissue adhesions.
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