The relationship between metabolic syndrome and oxidative stress in oral cancer patients with betel-quid chewing habit

• Main Authors: Chia-Hua Chang, 張家樺
• Other Authors: Ping-Ting Lin
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/rwny82

碩士 === 中山醫學大學 === 營養學研究所 === 104 === Oral cancer is the fifth leading causes of cancer death in Taiwan. According to 2005-2008 Nutrition and Health Survey in Taiwan, the prevalence rate of metabolic syndrome (MS) has been increased. The purpose of this study was to investigate the correlations between the components of MS and oxidative stress and inflammation in oral cancer patients who had betel-quid chewing habit. We recruited 100 oral cancer patients who had betel-quid chewing habit, and we measured waist circumferences, blood pressure, fasting glucose, lipid profiles, oxidative stress (malondialdehyde), antioxidant enzymes activity (superoxidase dismutase, catalase, glutathione peroxidase) and inflammation marker (high sensitivity C-reactive protein) in the present study. A total of 97 % of the subjects were males, 60 % of the subjects were diagnosed as MS, and 98 % of the subjects have quitted betel-quid chewing habit. The levels of fasting glucose and triglyceride were significantly positively correlated with oxidative stress, where the values of waist circumferences and blood pressure were significantly negatively correlated with antioxidant enzymes activities. In the components of MS, abdominal obesity and hypertension were significantly negatively correlated with antioxidant enzymes activities (catalase); hyperglycemia was significantly positively correlated with oxidative stress and inflammation; hypertriglyceridemia was significantly positively correlated with oxidative stress; and low HDL-C level was significantly positively correlated with inflammation. In conclusion, oral cancer patients who had betel-quid chewing habit may suffer from a higher level of oxidative stress that may lead to increase the risk of MS. Further studies are needed to find a way to lower the high level of oxidative stress in the patients with oral cancer, except to get rid of betel-quid chewing habits.