| Summary: | 碩士 === 中山醫學大學 === 口腔材料科學研究所 === 104 === Bony tissue was mainly composed of an inorganic salts / organic polymer nanocomposites. Cobalt as an inducer of hypoxia inducible factor in enhancing alveolar bone regeneration. This study was prepared of polycaprolactone / cobalt-substituted hydroxyapatite nanocomposites. Cobalt-substituted hydroxylapatite was synthesized by electrochemical deposition, the electrolyte is 42mM calcium nitrate and phosphate monobasic of 25mM aqueous ammonium, substituted amount of cobalt ions in the electrolyte solution is 10.6% (mol%). Stainless steel and titanium sheet as cathode and the anode, the synthesis of cobalt-substituted hydroxyapatite in deionized water and dried. Nanocomposites was prepared using a solvent casting method, and oleic acid as a surfactant, can improve apatite dispersion on membrane. It was found that the thermal stability of the membranes containing oleic acid has improved significantly, presumably to enhance the oleic acid powder dispersion caused. The characterization of nanocomposite membrane was observed, including chemical composition, surface morphology, biological activity and magnetism. The nanocomposite was immersed in simulated body fluid (SBF) under 37
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