Diagnosis of knee joint osteoarthritis using the non-invasively wireless wearable technique

• Main Authors: Jia-Fong Jhang, 張家豐
• Other Authors: Jia-Jung Wang
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/66797339699292068685

碩士 === 義守大學 === 生物醫學工程學系 === 104 === Degenerative osteoarthritis is a common disease in medical institutions. Therefore, it is very important and urgentto early diagnose the degeneration of knee joints.The purpose of the thesis was toimprove the wireless and wearable measurement system developed by our laboratory for non-invasive detection of osteoarthritis (OA) of knee joints. To validate its feasibility of the measurement system, the study recruited 125 subjects including 29 control participants (Group 1) and 96 OA patients (Group 2: OA-I, Group 3: OA-II and Group 4: OA-III&IV) in the Department of Orthopedics, E-Da Hospital. In human trials, those subjectswere asked to perform the active, passive swings,the step-forward and –backward motions, walking movement, and squatting movement. During these experiments, the vibration signals from the knee joints were recorded with the measurement system.The vibration signals generated by the normal and osteoarthritis joints wereanalyzed by using the frequency-domain techniques, Fast Fourier Transform (FFT). After filtering the requency components less than 5 Hz, the energy ratio of 5~200 Hz in the vibration signals recorded from the knee surface during the active swinging was significantly smaller in Group 1 than OA Group (lateral condyle: 32.22±7.69vs36.09±7.48%, p=0.012; mid-patella: 29.35±7.81 vs 33.77±9.25%, p=0.016; medial condyle: 35.09±11.03 vs 39.81±10.79 %, p=0.033). Recorded at the lateral condyle and mid-patella, the energy ratio of 400~1KHz in the the vibration signals was significantly greater in Group 1 than OA Group (mid-patella: 29.27±5.00 vs 27.05±4.63 %, p=0.021; mid-patella: 30.20±5.63 vs 27.60±5.57 %, p=0.022).Using the Median Frequencyuency (MDF), it was found that MDFwas significantly greater in Group 1 than OA Group (lateral condyle: 308.47±45.05 vs 287.39±48.98 Hz, p=0.032; mid-patella: 312.76±48.55 vs 288.50±56.40 Hz, p=0.030; medial condyle: 280.64±70.13 vs 252.34±68.69 Hz, p=0.045). Furthermore, at the mid-patella, Group 1 showed significant difference in MDF as compared with Group 2 (312.76±48.55 vs 281.09±63.14Hz, p=0.045). In addition, at the medial condyle, there was significant difference in MDF between Group 1 and Group 4 (280.64±70.13vs 215.89±74.48Hz, p=0.002). In summary, a wireless and wearable measurement system is improved in the thesis. Energy ratio of a specific frequency band of vibration signals can be used to distinguish the control from the OA knee joints. Moreover, the MDF parameter can be applied to differentiae the severity of OA knees.