Development of Titanium Alloy Surface Treatment Technology for Sustained Release of Growth Factors

• Main Authors: WANG, JHE-WEN, 王哲文
• Other Authors: WANG, MIN-WEN
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/j7reun

碩士 === 國立高雄應用科技大學 === 機械與精密工程研究所 === 104 === This research project aims to develop a porous surface treatment technology with a sustained release of growth factors. It contains the following two parts. (1) To develop a surface treatment technology that promotes bone tissue to grow inside the implants, we produced porous implants by 3D printing firstly. Then we used surface treatment to create crater structures on the pores of implants. By co-deposition method, the calcium, phosphorus and BMP-2 in the crater structures, the growth of bone tissue can be improved. While these implants are in vivo, their calcium, phosphorus and BMP-2 are sustained released, inducing new bones to grow into the pores. With this surface treatment, it will increase the contact area between new bone and the implant thus enhances the stability of implants. (2) In the animal experiment, we implanted the Ti6Al4V skullcaps which were treated by surface treatment and co-deposition method in rabbits' heads. After the removing torsion test and the observation of new bones growth, the results show that Micro-arc Oxidation at 200 V for 10 minutes and co-deposition at 2 V for 30 minutes filling the surface craters with calcium, phosphorus and BMP-2 can lead the ratio of calcium and phosphorus to 1.67. We also found that BMP-2 has a mechanism of long-term release, and then reach to 154.36 ng/ml after 28-day observation. After 12-week animal experiment, the new bones grew into implants at the depth of 10 mm, representing the new bones growth rate can attain 90%. Moreover, the pulling-out torsion is 17.8% higher than the torsion of samples treated by MAO. That is, the sustained release of calcium, phosphorus and BMP-2 can improve the stability of implants.