| Summary: | 碩士 === 國立中興大學 === 化學系所 === 104 === Canagliflozin, Ipragliflozi and Dapagliflozin are SGLT2 inhibitors that have potential use in the treatment of type II diabetes. All of them are C−Glycoside structure. Starting with 2-clorothiophene, Benzothiophene and 2- ethoxybenzene furnishes two thiophene structures and one benzene structure. After C-glycosylation reactions afford three C−Glycoside structures, reduction a methoxy, Canagliflozin, Ipragliflozi and Dapagliflozin were obtained.
In second part of thesis, synthesis of analogues of ganglioside Hp-s1 and DSG-A is presented. In order to optimize the neuritogenic activity, we change the oxygen atom between central glucosyl moiety and phytosphingosine part with sulfur atom of ganglioside Hp-s1 and DSG-A to syntheisized new analogues 67 and 70.
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