(1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation

(1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation

碩士 === 國立中興大學 === 化學系所 === 104 === Canagliflozin, Ipragliflozi and Dapagliflozin are SGLT2 inhibitors that have potential use in the treatment of type II diabetes. All of them are C−Glycoside structure. Starting with 2-clorothiophene, Benzothiophene and 2- ethoxybenzene furnishes two thiophene struc...

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Main Authors: Chih-Wu Liang, 梁致武
Other Authors: Shun-Yuan Luo
Format: Others
Language:zh-TW
Published: 2016
Online Access:http://ndltd.ncl.edu.tw/handle/87363228345742914477
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spelling ndltd-TW-104NCHU50650682017-01-11T04:08:09Z http://ndltd.ncl.edu.tw/handle/87363228345742914477 (1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation (1) 合成SGLT2抑制劑Canagliflozin及Ipragliflozin(2) 利用s-醣苷化反應合成Hp-s1及DSGA衍生物 Chih-Wu Liang 梁致武 碩士 國立中興大學 化學系所 104 Canagliflozin, Ipragliflozi and Dapagliflozin are SGLT2 inhibitors that have potential use in the treatment of type II diabetes. All of them are C−Glycoside structure. Starting with 2-clorothiophene, Benzothiophene and 2- ethoxybenzene furnishes two thiophene structures and one benzene structure. After C-glycosylation reactions afford three C−Glycoside structures, reduction a methoxy, Canagliflozin, Ipragliflozi and Dapagliflozin were obtained. In second part of thesis, synthesis of analogues of ganglioside Hp-s1 and DSG-A is presented. In order to optimize the neuritogenic activity, we change the oxygen atom between central glucosyl moiety and phytosphingosine part with sulfur atom of ganglioside Hp-s1 and DSG-A to syntheisized new analogues 67 and 70. Shun-Yuan Luo 羅順原 2016 學位論文 ; thesis 178 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 碩士 === 國立中興大學 === 化學系所 === 104 === Canagliflozin, Ipragliflozi and Dapagliflozin are SGLT2 inhibitors that have potential use in the treatment of type II diabetes. All of them are C−Glycoside structure. Starting with 2-clorothiophene, Benzothiophene and 2- ethoxybenzene furnishes two thiophene structures and one benzene structure. After C-glycosylation reactions afford three C−Glycoside structures, reduction a methoxy, Canagliflozin, Ipragliflozi and Dapagliflozin were obtained. In second part of thesis, synthesis of analogues of ganglioside Hp-s1 and DSG-A is presented. In order to optimize the neuritogenic activity, we change the oxygen atom between central glucosyl moiety and phytosphingosine part with sulfur atom of ganglioside Hp-s1 and DSG-A to syntheisized new analogues 67 and 70.
author2 Shun-Yuan Luo
author_facet Shun-Yuan Luo
Chih-Wu Liang
梁致武
author Chih-Wu Liang
梁致武
spellingShingle Chih-Wu Liang
梁致武
(1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation
author_sort Chih-Wu Liang
title (1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation
title_short (1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation
title_full (1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation
title_fullStr (1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation
title_full_unstemmed (1) Synthesis of SGLT2 inhibitors Canagliflozin and Ipragliflozin(2) Synthesis of Ganglioside Hp-s1 and DSGA Analogues with S-Glycosylation
title_sort (1) synthesis of sglt2 inhibitors canagliflozin and ipragliflozin(2) synthesis of ganglioside hp-s1 and dsga analogues with s-glycosylation
publishDate 2016
url http://ndltd.ncl.edu.tw/handle/87363228345742914477
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