| Summary: | 碩士 === 國立中興大學 === 食品暨應用生物科技學系所 === 104 === Hypertension is the most common cardiovascular diseases that is caused by the blood vessels have persistently raised pressure, and has emerged as one of the major causes of mortality and morbidity worldwide. Nω-nitro-L-arginine methyl ester (L-NAME) can inhibit the NO synthesis and induced hypertension in mice. The study was divied into two parts. The first part of this study was to investigate the therapeutic effects of low, medium and high dosages of Camellia brevistyla (Hayata) Coh.-Stuart fruit oil (CBFO) in L-NAME induced hypertensive C57BL/6J mice model. The results showed that CBFO groups didn''t efficiently reduced the blood pressure. Otherwides, fed with the high dosage of CBFO significantly decreased the levels of fasting glucose, malondialdehyde (MDA) and protein carbonyl；also obviously increased the values of serum high-density lipoprotein cholesterol (HDL-C) and HDL-C/LDL-C ratio compared to other groups (p<0.05). The levels of hepatic and renal function markers such as ALT, AST, BUN and creatinine in all CBFO mice were significantly lower than that of L-NAME mice. The aorta wall thicknesses of CBFO groups were thinner than L-NAME group. These results suggest that camellia oil can modulate the levels of blood lipid and potentially reduce the risk of metabolic syndrome. The second part of this study was to investigate the effects of low, medium and high dosages of Camellia brevistyla (Hay.) Coh.-Stuart seed pomace ethanol extract (CBPE) in L-NAME induced hypertensive BALB/c mice model. The results showed that all doses of CSPE were significantly decreased the systolic and diastolic blood pressure, intima media thickness of thoracic aorta and levels of MDA adducts in liver compared to L-NAME group (p<0.05). These results suggest that CBPE has great potential in blood pressure control and also reduces the lipid-peroxides in liver for lowing the risk of cardiovascular disease.
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