| Summary: | 碩士 === 國立成功大學 === 化學系 === 104 === According to the recent literatures, most of the methods use the radical initiator or metal to generate radical group. Afterward the radical group can undergo the addition reaction with unsaturated bond of the reactant, then the reactant do the cyclization to synthesis indol-2-one further. In this thesis, we synthesis the compounds which have a bromide group as reactants. We use the copper(II) acetylacetonate as an oxidant, and phenanthroline as a ligand to react with our reactant. The reactant may generate stably radical, and then that do cyclization reaction directly. The results show that we can use this method to synthesize a variety of indol-2-one derivatives, and this method is applicable to a variety of functional groups.
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