Coordinating Hollow CuS Nanospheres for Near-Infrared Light Triggering Enhanced Ultrasound Imaging and Photothermal Therapy

• Main Authors: Sheng-JungWang, 王笙容
• Other Authors: Chen-Sheng Yeh
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/70003921147796000390

碩士 === 國立成功大學 === 化學系 === 104 === In this study, we provide a strategy of the metal ion-ligand coordination feature for the hydrophilic hollow nanostructures showing the capability of gas release to fulfill the echogenicity for the ultrasound imaging. We began with solid Cu2O nanoparticles, followed by a modified Kirkendall process to convert solid Cu2O into hollow porous CuS. The ferric ion (Fe3+) was used as the coordination center to bridge both dopamine and bicarbonate. The dopamine served as the bidentate ligand to coordinate Fe3+, while the bicarbonate coordinated to Fe3+ in a monodentate manner. The coordinated CuS nanoparticles revealing NIR light-induced hyperthermia resulted in the decomposition of bicarbonate into CO2 serving as echogenic source and the performance in inhibition of the tumor growth.