| Summary: | 碩士 === 國立成功大學 === 電機工程學系 === 104 === Next generation sequencing (NGS) technologies have brought an unprecedented scale of genomic data to biologists. NGS technologies, unlike array-based profiling technologies, can provides the read count variation at the base level in a transcript rather than a single expression value. Such base-level read coverage has been used in many research field. Calculating the base-level read coverage requires alignment of numerous reads on reference genome, but the result is difficult to read and analysis by human. Many viewers, such as Savant, Tablet and Integrative Genomics Viewer, has been developed to solve this problem, converting those read alignment into friendly graphic profile. However, to our best knowledge, none of them can timely visualize a genome-wide base-level read coverage in an interactive environment.
This study proposes an efficient visualization pipeline for NGS data and implements a lightweight read coverage viewer with the proposed pipeline. The proposed viewer provides friendly user interface and can rapidly response to user’s input.
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