| Summary: | 碩士 === 國立體育大學 === 運動科學研究所 === 104 === Purpose: Diabetes (one of non-communicable diseases) is serious due to its complications, such like, cardiovascular ailments, neuropathy, nephropathy, retinopathy, wound gangrene and sexual impotence. Diabetes and associated chronic conditions are rapidly emerging as major health problems. In clinical, there were different drugs for diabetes treatment on different mechanisms. However, there were limited studies on the efficacy of electric stimulations on diabetes therapeutic application. In current study, we try to evaluate the effect of Resonant waves (RW) transcutaneous electrical nerve stimulator (TENS) on diabetes modulation as an alternative medicine. Methods: A total of 36 male ICR mice of 6 weeks old were randomly divided into 4 groups (1) Control, (2) Resonant waves TENS only (RW), (3) DM, (4) DM with Resonant Waves TENS (DM＋RW). During 8 weeks treatments, the diabetes-associated assessments included body weight, diet utilization, blood glucose measurement, other biochemistries and histopathological observations. Results: The diabetes animal model induced by STZ had 180 mg/dL fasting blood glucose (GLU-AC) before TENS intervention. After 3 and 6 weeks administration, the GLU-AC of DM+TENS group significantly decreased 31.97% and 50.82% (p <0.0001), respectively, as compared to DM group and the OGTT also demonstrated the similar significant results. The diabetic syndromes of polydipsia and polyphagia were also significantly ameliorated by TENS intervention. In other biochemical indexes, the glycated hemoglobin (HbA1c), hyperinsulinemia, liver functions (AST & ALT) and kidneys function (BUN & Creatinine) were also significantly mitigated by TENS under diabetes model. The histological observation also showed the TENS administration improved the diabetes-related pathological characteristics in liver, kidney and pancreas tissues. Conclusion: Our results suggest that administration of TENS could significantly improve diabetes animal model on blood sugar homeostasis, diabetic polydipsia, biochemistries, and tissue damage. In the health conditions, the TENS didn’t exist obvious side effects on assessments. Therefore, the TENS could be potential on alternative medicine or supportive applications to future DM therapeutics.
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