| Summary: | 碩士 === 國立體育大學 === 運動科學研究所 === 104 === Purpose: To evaluate whether the extracts of Ludwigia octovalvis (Jacq.) Raven (LOE) is able to ameliorate the physical fatigue, increase exercise performance, or anti-fatigue functions. Methods: A total of 32 male ICR mice were divided into four groups (8 mice/group): the control group without treatment, and the treatment with LOE at a dosage of 61.5, 123, 307.5 mg/kg/day, respectively, and designed as LOE-1X, -2X or 5X groups. After four weeks, all mice were tested for exercise performance and anti-fatigue functions, including forelimb grip strength, endurance performance in a 5% body weight-loaded swimming test, and serum levels of lactate, ammonia, glucose, urea nitrogen concentration, and creatine kinase after a 15-min exercise challenge. Result: The LOE-treated animals have a significant increase in endurance swimming performance, and in a dose-depend manner. In addition, LOE-treated mice have a significant reduction of fatigue- or muscle injury-associated biomarkers: serum lactate, ammonia, and CK levels post an acute exercise challenge.
In addition, the LOE-1X, -2X or -5X groups could increase blood glucose levels by 24.5%, 29.0% and 31.5%, respectively, than control group.
Conclusion: The supplementation with LOE beneficial effects on performance improvement and anti-fatigue function.
Keywords: Ludwigia, Exercise performance, Lactate, Ammonia
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