Synthesis Small Molecular Contain Sulfur、Selenium Heterocycle Biologic Compounds by One-pot under Ultrasonication and Synthesis Antrodia Cinnamomea of Mycelium AnaloguesSynthesis Small Molecular Contain Sulfur、Selenium Heterocycle Biologic Compounds by One-pot under Ultrasonication and Synthesis Antrodia Cinnamomea of Mycelium Analogues

博士 === 國立交通大學 === 應用化學系碩博士班 === 104 === In organic synthetic chemistry, the use of ultrasound to synthetic drugs are very rare, and this paper is the use of ultrasound, to assist the synthesis of a pot of 2-iminothiazoles, 2-iminoselenazoles, ketosulfides three biologically active hetero ring molecu...

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Bibliographic Details
Main Authors: Chang, Wong-Jin, 張萬鈞
Other Authors: Sun, Chung-Ming
Format: Others
Language:zh-TW
Published: 2015
Online Access:http://ndltd.ncl.edu.tw/handle/97n527
Description
Summary:博士 === 國立交通大學 === 應用化學系碩博士班 === 104 === In organic synthetic chemistry, the use of ultrasound to synthetic drugs are very rare, and this paper is the use of ultrasound, to assist the synthesis of a pot of 2-iminothiazoles, 2-iminoselenazoles, ketosulfides three biologically active hetero ring molecules. The result was very successful, with very good yields. And very lucky, we also get 2-iminoselenazoles intermediate X-ray diffraction diagram (Compound 56) From this we can surmise that it was found to generate response mechanisms. In the synthesis of 2-iminothiazoles when we get X-ray diffraction diagram (compound 31d) found out we synthesized some reports in the product structure is not thought imidazole-2-thiones, but 2-iminothiazoles. In another section, the extraction of Antrodia synthesis of derivatives, also found that some 5-lipoxygenase inhibiting the biological activity of the protein structure. These synthetic compounds Antrodia derivatives in, we accidentally discovered derivative if Lawesson's reagent and number 10, will be 2-methylpent-2-ene removed. This is a before nobody had reported an experiment.