| Summary: | 博士 === 國立中央大學 === 光機電工程研究所 === 104 === Breast cancer has long-term remained the highest incidence rate, and the 4th highest mortality rate for woman in Taiwan. Based on routine X-ray breast mammography, relatively safe near infrared diffuse optical imaging (NIR DOI) is emerging as a potential imaging technique for breast cancer detection. Compared with the mammography which gives only the structural images of breast tissue, DOI provides not only the structural information, but also the functional images including oxyhemoglobin, deoxyhemoglobin, lipid and water content as well as the morphological images including nucleus size and volume fraction. This research project aims to obtain structural, functional and morphological contents of breast tissue using a multi-spectral DOI image reconstruction approach.
In this study, we propose and implement three-dimensional (3-D) ring-scanning equipment for near-infrared (NIR) diffuse optical imaging to screen breast tumors under prostrating examination. This equipment has the function of the radial, circular, and vertical motion without compression of breast tissue, thereby achieving 3-D scanning; furthermore, a flexible combination of mZnS design of illumination and detection can be configured for the required resolution. The research proceeds to the development of prostrate-type DOI system based on previous basis, such as frequency-domain measurement system, inverse computation scheme for optical-property images, and algorithms for the purpose of rapid convergence, edge-preserving for better tumor detection. Results of this study showed phantom experiment confirmed that the 3-D scanning system can distinguish the geometric and optical characteristics difference between tumors and background.
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