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• Main Authors: Chun-Cheng Wu, 吳浚晟
• Other Authors: Min-Chun Pan
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/28903863904810122632

碩士 === 國立中央大學 === 光機電工程研究所 === 104 === The incidence rate and mortality rate of breast cancer is ranked first and fourth in Taiwan respectively, and statistical data indicate the 5-year survival rate of stages 0 breast cancer was 97.70%. Therefore, the development of a safe and effective diagnostic modality is an important issue. Our laboratory developed near-infrared diffuse optical tomography (NIR-DOT) system, it distinguished normal tissue and tumor tissue by the optical characteristics. The research developed ∅ 300 mm double integrating sphere measurement system to establish an archive for optical coefficients of breast tissue. We confirm the stability of system by element characteristic test, experimental process design and system factor analysis. Measuring the optical characteristics of the phantom, pigskin and fat to confirm reliability of this system. We conducted clinical trial at the Tri-Service General Hospital (TSGH), and measured optical characteristics of breast tissue biopsy and correseonded sliced pathological analysis report to gradually establish an archive for optical coefficients of breast tissue in Taiwan. According to the archive, we odtain optical characteristics of tissue to determine tissue lesions such as infiltrating carcinoma, carcinoma in situ and fibroblasts proliferation. Based on test results, We acquired absorption coefficeut (μa) and scattering coefficient (μs') from breast tissue biopsy. We compared tumor tissue to normal tissue with the contrast of μa is 2.00 ± 1.28 and μs' is 1.37 ± 0.35. Furthermore, the μa of tumor separated infiltrating carcinoma and carcinoma in situ, and the contrast is 1.50 ± 0.50 and 4.13 ± 1.43. The μs' of tumor can determine that there is the fibroblasts proliferation or not, and the contrast is 1.19 ± 0.22 and 2.06 ± 0.99. Because of the optical characteristics of the physiological tissue, it is used as an important indicator of tissue lesions.