The role of cystathionine gama-lyase in prostate cancer metastasis

• Main Authors: Jo-Ting Huang, 黃若婷
• Other Authors: Lu-Hai Wang
• Format: Others
• Language: en_US
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/22668958813092911054

碩士 === 國立臺灣大學 === 分子與細胞生物學研究所 === 104 === Prostate cancer is one of the most common cancers and the second leading cause of death from cancer in men. Metastatic prostate cancer most commonly spreads to the bones and lymph nodes. Bone metastasis is painful and has no cure. Thus, the main goal of this study is to identify potential drug targets in treating prostate cancer bone metastasis. In this study, the role of a metabolic enzyme, cystathionine gamma-lyase (CTH), was investigated. We found that CTH was up-regulated in bone-metastatic prostate cancer cells, and it positively regulated cell migration, cell invasion and angiogenesis. CTH enhanced expression of IL-1β, resulting in increased phosphorylation of p65 subunit of NF-κB. p65 nuclear translocation was promoted by CTH through H2S and/or IL-1β. Treatment of H2S or IL-1β increased cell invasion and angiogenesis. Collectively, our data suggests that CTH likely plays an important role in promoting prostate cancer cell invasion and metastasis through production of H2S and IL-1β.