Water Soluble Curcumin Preparation Via Electrospinning and Flash Nanoprecipitation
碩士 === 國立臺灣科技大學 === 化學工程系 === 104 === Curcumin is a natural occurring phenolic substance, which has wide range of pharmacological activities, such as anti-inflammatory, antioxidant, antitumor, antibacterial and anticancer properties. However, its limited aqueous solubility restricts its bioavailabil...
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ndltd-TW-104NTUS53420632017-09-10T04:30:09Z http://ndltd.ncl.edu.tw/handle/60658881959157887425 Water Soluble Curcumin Preparation Via Electrospinning and Flash Nanoprecipitation 利用靜電紡絲及快速奈米沉澱技術製備水溶性薑黃素之研究 Shu-Chi Lin 林淑淇 碩士 國立臺灣科技大學 化學工程系 104 Curcumin is a natural occurring phenolic substance, which has wide range of pharmacological activities, such as anti-inflammatory, antioxidant, antitumor, antibacterial and anticancer properties. However, its limited aqueous solubility restricts its bioavailability. Polyvinyl pyrrolidone (PVP) is known as a biocompatible and highly water soluble polymer. Solid dispersion of curcumin in electrospun PVP (CUR-PVP) fibrous mat was prepared to increase its solubility and dissolution rate in aqueous solution. Physical characterizations of CUR-PVP by FE-SEM, FTIR-ATR, and XRD were carried out. The average diameter of CUR-PVP fiber in the mat is about 1μm. CUR-PVP can be easily dissolved in water with significantly improve curcumin solubility from 0.39±0.05μg/mL to 491.86±31.27μg/mL. The enhanced solubility is mainly due to the stable chemical complex interaction between curcumin and PVP. CUR-PVP not only can increase DPPH free radical scavenging activity as well as antioxidant activity measured by CUPRAC assay and ferric thiocyanate method but also curcumin photochemical stability. Curcumin encapsulated in acetylated starch (Cur@AS) nanoparticles of 47-58 nm in diameter was also prepared by flash nanoprecipitation to increase the solubility of curcumin. The highest production yield of Cur@AS was 92.9% with curcumin loading capability of 8.19% and curcumin loading encapsulation efficiency of 71.0%. Cur@AS nanoparticles not only can increase curcumin solubility but also increase its antioxidant activity and photochemical stability. Cheng-Kang Lee 李振綱 2016 學位論文 ; thesis 96 zh-TW |
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碩士 === 國立臺灣科技大學 === 化學工程系 === 104 === Curcumin is a natural occurring phenolic substance, which has wide range of pharmacological activities, such as anti-inflammatory, antioxidant, antitumor, antibacterial and anticancer properties. However, its limited aqueous solubility restricts its bioavailability. Polyvinyl pyrrolidone (PVP) is known as a biocompatible and highly water soluble polymer. Solid dispersion of curcumin in electrospun PVP (CUR-PVP) fibrous mat was prepared to increase its solubility and dissolution rate in aqueous solution. Physical characterizations of CUR-PVP by FE-SEM, FTIR-ATR, and XRD were carried out. The average diameter of CUR-PVP fiber in the mat is about 1μm. CUR-PVP can be easily dissolved in water with significantly improve curcumin solubility from 0.39±0.05μg/mL to 491.86±31.27μg/mL. The enhanced solubility is mainly due to the stable chemical complex interaction between curcumin and PVP. CUR-PVP not only can increase DPPH free radical scavenging activity as well as antioxidant activity measured by CUPRAC assay and ferric thiocyanate method but also curcumin photochemical stability.
Curcumin encapsulated in acetylated starch (Cur@AS) nanoparticles of 47-58 nm in diameter was also prepared by flash nanoprecipitation to increase the solubility of curcumin. The highest production yield of Cur@AS was 92.9% with curcumin loading capability of 8.19% and curcumin loading encapsulation efficiency of 71.0%. Cur@AS nanoparticles not only can increase curcumin solubility but also increase its antioxidant activity and photochemical stability.
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author2 |
Cheng-Kang Lee |
author_facet |
Cheng-Kang Lee Shu-Chi Lin 林淑淇 |
author |
Shu-Chi Lin 林淑淇 |
spellingShingle |
Shu-Chi Lin 林淑淇 Water Soluble Curcumin Preparation Via Electrospinning and Flash Nanoprecipitation |
author_sort |
Shu-Chi Lin |
title |
Water Soluble Curcumin Preparation Via Electrospinning and Flash Nanoprecipitation |
title_short |
Water Soluble Curcumin Preparation Via Electrospinning and Flash Nanoprecipitation |
title_full |
Water Soluble Curcumin Preparation Via Electrospinning and Flash Nanoprecipitation |
title_fullStr |
Water Soluble Curcumin Preparation Via Electrospinning and Flash Nanoprecipitation |
title_full_unstemmed |
Water Soluble Curcumin Preparation Via Electrospinning and Flash Nanoprecipitation |
title_sort |
water soluble curcumin preparation via electrospinning and flash nanoprecipitation |
publishDate |
2016 |
url |
http://ndltd.ncl.edu.tw/handle/60658881959157887425 |
work_keys_str_mv |
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