| Summary: | 碩士 === 靜宜大學 === 食品營養學系 === 104 === Alzheimer's disease (AD) is a disorder with progressive dementia and degeneration of congnitive function. Many evidences showed some factors, such as inflammation, neurotrophins, amyloid protein accumulation, had great impact on Alzheimer's disease. Coffee was produced by coffeeberry, coffeeberry is oval cherry-like fruit produced by coffee tree. Coffee could improve cognitive function, which might be effective on preventing or treating Alzheimer's disease. However, the effects of coffeeberry on learning and memory is still unclear. This study investigated the effect of coffeeberry on learning and memory in senescence accelerated mice. Three-month old SAMP8 (Senescence accelerated prone mice P8) mice were divided into control, low, medium and high dose of coffeeberry groups. In 12 weeks experiment period, body weight, food intake, single-trial passive avoidance test and active shuttle avoidance test were recorded. After sacrificed, we evaluated brain β amyloid (Aβ) related factors such as amyloid precursor protein (APP), beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1), and inflammatory factors such as cyclooxygenase-2 (COX-2), induction nitric oxide synthases (iNOS), and neurotrophins such as brain derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB). The results showed SAMP8 mice fed coffeeberry tended to improve the learning and memory. In addition, coffeeberry could increase BDNF and CREB expressions, and reduced COX-2 and BACE-1 expressions, whereas the iNOS did not differ among group. In summary, the supplementation of coffeeberry could increase neurotrophic factor, decreased amyloid protein deposition, reduced inflammatory response, then enhanced the learning and memory performance.
|
|---|
