Development of portable plate for blood-plasma separation

• Main Authors: Hung-Chih Tseng, 曾弘智
• Other Authors: 嚴孝全
• Format: Others
• Online Access: http://ndltd.ncl.edu.tw/handle/95g23d

碩士 === 國立臺北科技大學 === 機電整合研究所 === 104 === Plasma contains various biomarkers and disease-causing viruses, bacteria, and autoimmune antibodies, etc., they can reflect a variety of warning of the body, including: myocardial infarction, Alzheimers disease, and some cancers etc., in order to detect being not disturbed by blood cells, biochips must first obtain plasma before testing. Purpose of this study is to design portable separating whole blood platform that use polycarbonate substrate having a slope recess. And using MEMS technology produce molds, and then turning model microfluidic channels of PDMS. After two combine together, it applies principle of Degas-driven Flow drive blood into the microfluidic channel, its main advantage one is not need external power, another is the bio-sensor chip and polycarbonate substrate as one ,and the other is for enhancing separation reliability, and add more micro-beads filter. It’s make 10 µL whole blood separate plasma around 5 minutes.