Study on Tumor Ablation with OCT-Guided Laser Surgery

• Main Authors: Wei Chuan Chen, 陳韋銓
• Other Authors: M. T. Tsai
• Format: Others
• Language: zh-TW
• Published: 2017
• Online Access: http://ndltd.ncl.edu.tw/handle/33k553

碩士 === 長庚大學 === 電機工程學系 === 105 === Cancer has become the top cause of death for several years in Taiwan. Also it take a large part in the death toll across the world. But if we can find tumor early and remove it clearly, cancer is possibly to be cure. Malignant tumor growth needs more nutrient. So when the tumor turns to malignant tumor. We can find the messy angiogenesis happened and observe the tumor structure changes by medical imaging technique, to recognize if the tumor lesion. Combining with medical imaging technique and surgery treatment to decrease the tumor size and remove all the tumor. Furthermore to avoid the tumor recurrent again, medical imaging technique can be helpful to follow up after operative. Optical coherence tomography (OCT) is a noninvasive, high speed, high resolution scanning technology, based on principle of interference. OCT can provide 2D/3D structure image without damage the sample. Currently OCT has wildly used in many clinical use, such as ophthalmology, dermatology, and Dentistry. In this thesis, we used OCT system as a medical imaging technique assist for cancer treatment. After tumor implanted into the mouse, we scanned 2D/3D image at the same region. In order to observe structure image and angiogenesis image. Furthermore, analyzed the characteristics of angiogenesis which caused by tumor growth, and quantified of vascular density information. We used OCT system guiding laser to treat the tumor, observed the structure image of ablation, and analyzed the laser thermal effect of angiogenesis. After the treatment finished, we still followed up the tumor region for several days by OCT system. Using the OCT system proposed in this thesis, we can observe the preoperative image, operative image and track the image after treatment. Besides with the guidance function, we can treat the specific small area, and also decline the side effect with other therapy. Moreover it can reduce time of treatment and so on…. According to the result, our system can effectively observe the malignant tumor growth, angiogenesis phenomenon, and guide laser to remove the tumor entire cells clearly.