Studies on the Development of Medicines for Fighting Neurodegenerative Diseases: Synthesis of sphingosine and Ganglioside Neu5GcHp-s1 and it’s Analogues with Various Ceramides
碩士 === 中原大學 === 化學研究所 === 105 === This paper aims to complete neurodegenerative activity of ganglioside Hp-s1 analogues Hp-SJ1、Hp-SJ2、Hp-SJ3 synthesis, we used chemoselective glycosylation reaction and [1+1+2] synthetic strategy. In addition, the synthesis of the sphingosine derivative xyl-13 will b...
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Format: | Others |
Language: | zh-TW |
Published: |
2017
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Online Access: | http://ndltd.ncl.edu.tw/handle/64994835480195387779 |
Summary: | 碩士 === 中原大學 === 化學研究所 === 105 === This paper aims to complete neurodegenerative activity of ganglioside Hp-s1 analogues Hp-SJ1、Hp-SJ2、Hp-SJ3 synthesis, we used chemoselective glycosylation reaction and [1+1+2] synthetic strategy.
In addition, the synthesis of the sphingosine derivative xyl-13 will be carried out to synthesize the ceramide.
The synthesis of Hp-SJG1, Hp-SJG2 and Hp-SJG3 main architectures NGLA-1, NGLR-1 and NGLM-1 has been completed.
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