Glycosidic Modification of Honokiol or Magnolol with Monosaccharide and its Prodrug Implication

碩士 === 輔仁大學 === 化學系 === 105 === The synthesis of magnolol was introduced at the beginning, and the product was obtained by four steps (protection, Grignard, deprotection, metal bonding).Then use the mitsunobu reaction let the honokiol and magnolol were then synthesized with sugar-donor (acetylated m...

Full description

Bibliographic Details
Main Authors: Luo, Chin-Hung, 駱慶鴻
Other Authors: Chen, Chien-Sheng
Format: Others
Language:zh-TW
Published: 2017
Online Access:http://ndltd.ncl.edu.tw/handle/kr8668
Description
Summary:碩士 === 輔仁大學 === 化學系 === 105 === The synthesis of magnolol was introduced at the beginning, and the product was obtained by four steps (protection, Grignard, deprotection, metal bonding).Then use the mitsunobu reaction let the honokiol and magnolol were then synthesized with sugar-donor (acetylated mannopyranose, acetylated xylopyranose).Try other ways of synthesis, to obtain the product of one form.Followed by cell culture in a biological laboratory and cultured of the synthesized product to cells for subsequent bioassays (Western blot, ELISA, RT PCR, etc.), as compared to last year.