Reversal Glycosylation with Sulfonate Leaving-Group in Glycosyl Acceptor
碩士 === 輔仁大學 === 化學系 === 105 === Part 1: A reversal glycosylation method is proposed to introduce a sulfonate group at the sugar receptor and a hydroxyl group at the anomeric carbon of the saccharide. The sulfonic acid ester group of the sugar receptor is catalytically converted to the saccharide bod...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2017
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| Online Access: | http://ndltd.ncl.edu.tw/handle/ggw4b3 |
| Summary: | 碩士 === 輔仁大學 === 化學系 === 105 === Part 1: A reversal glycosylation method is proposed to introduce a sulfonate group at the sugar receptor and a hydroxyl group at the anomeric carbon of the saccharide. The sulfonic acid ester group of the sugar receptor is catalytically converted to the saccharide body by alkaline or acidic conditions, the leaving group is constructed, followed by a basic or acidic catalyzed glycosylation.
Part 2: Try to use monosaccharides with simple protection to connect with diol and unsubstituted pyridine at anomeric carbon, selectively generate carbohydrate- Modified 1- (Substituted alkyl)-2 (1H) Pyridones.
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